Injections after endometriosis surgery

After endometriosis surgery, it is usually necessary to inject gonadotropin-releasing hormone agonists or progesterone drugs as directed by the doctor. The main drugs include leuprorelin, goserelin, triptorelin, dienogest, medroxyprogesterone, etc. Postoperative injections can help suppress ovarian function and reduce the risk of disease recurrence, and individualized treatment plans must be strictly followed.

1. Lupron

Lupron injection inhibits the secretion of gonadotropins by the pituitary gland, reduces estrogen levels, and causes ectopic endometrium to atrophy. It is suitable for adjuvant treatment after surgery for moderate to severe endometriosis. Low estrogen reactions such as hot flashes and osteoporosis may occur. Bone density needs to be monitored regularly during medication. Common dosage forms include leuprolide acetate sustained-release microsphere injection.

2. Goserelin

Goserelin implants can sustainably release the drug for up to 28 days and suppress ovarian function by downregulating pituitary receptors. It is mostly used to prevent postoperative recurrence, which may cause side effects such as vaginal dryness and mood swings. It is recommended to supplement it with calcium. The commonly used clinical dosage form is goserelin acetate sustained-release implant.

3. Triptorelin

Triptorelin injection can reversibly inhibit ovarian hormone secretion and control residual lesion activity. It is suitable for patients with uterine adenomyosis. Reactions such as headache and joint pain may occur during medication, and it is necessary to avoid using it in combination with glucocorticoids. Common dosage forms include triptorelin acetate injection.

4. dienogest

Dienogest tablets are highly selective progesterone receptor agonists that can directly inhibit intimal cell proliferation. It is suitable for long-term management of young patients. It may cause irregular bleeding and requires continuous medication for 3-6 months. The main dosage form is dienogest tablets.

5. Medroxyprogesterone

Medroxyprogesterone injection achieves lesion regression by transforming the endometrium and is mostly used in patients with limited economic conditions. Pay attention to weight gain and risk of blood clots, and limit high-fat diet during medication. Commonly used dosage forms include medroxyprogesterone acetate injection.

During the postoperative injection treatment, you should maintain a balanced diet, supplement with appropriate amounts of vitamin D and calcium, and avoid strenuous exercise. It is recommended to review pelvic ultrasound and hormone levels every 3 months. If abnormal vaginal bleeding or severe bone and joint pain occurs, timely follow-up is required. It is recommended to take contraceptive measures within 6 months after the end of treatment, and fertility needs will be assessed after menstruation resumes.