What to do if premature ovarian failure does not ovulate

Premature ovarian failure and non-ovulation can be intervened by adjusting lifestyle, hormone replacement therapy, ovulation induction therapy, traditional Chinese medicine conditioning, assisted reproductive technology, etc. Premature ovarian failure is usually caused by genetic factors, autoimmune diseases, iatrogenic injuries, viral infections, environmental toxins and other reasons.

1. Adjust your lifestyle

Maintaining a regular schedule can help improve endocrine disorders and ensure 7-8 hours of sleep every day. Do moderate aerobic exercise such as brisk walking and swimming, 3-5 times a week, 30 minutes each time. The diet needs to increase in soy products, deep-sea fish and other foods rich in phytoestrogens and omega-3 fatty acids, and avoid bad habits such as smoking and drinking.

2. Hormone replacement therapy

Estradiol valerate tablets/estradiol cyproterone tablets composite packaging, tibolone tablets and other drugs are commonly used to supplement estrogen to improve symptoms such as hot flashes and osteoporosis. Breast and endometrium conditions need to be assessed before treatment, and hormone levels should be monitored regularly during treatment. The treatment needs to be continued until the average menopausal age and cannot be stopped on your own.

3. Ovulation induction treatment

For those with fertility needs, drugs such as clomiphene citrate capsules and urinary gonadotropin for injection can be used to induce ovulation. Follicular development needs to be monitored by ultrasound during treatment to avoid multiple pregnancy and ovarian hyperstimulation syndrome. The success rate of this program is about 30-40%. It is recommended to adjust the program after 3 cycles of failure.

4. Traditional Chinese Medicine Conditioning

People with kidney deficiency can take Zuogui Pills or Yougui Pills. People with liver stagnation can take Xiaoyao Pills, along with acupuncture at acupuncture points such as Guanyuan and Sanyinjiao. Traditional Chinese medicine cycle therapy commonly uses medicinal materials such as Ziheche and Cuscuta, which require continuous conditioning for 3-6 months. During treatment, the basal body temperature curve should be recorded to evaluate the efficacy.

5. Assisted reproductive technology

For those who are ineffective in promoting ovulation through drugs, in vitro fertilization-embryo transfer technology may be considered. The antagonist program or minimal stimulation program is used to obtain eggs, and the embryos are cryopreserved and then transplanted in a hormone replacement cycle. The single-cycle live birth rate for patients under 40 years old can reach 20-30%, and ovarian reserve function needs to be fully evaluated.

It is recommended to consume 300 ml of soy milk or 100 grams of tofu daily to supplement phytoestrogens, and eat salmon 2-3 times a week to supplement high-quality protein. Keep your BMI between 18.5-23.9 and avoid excessive dieting. You can practice yoga or meditation to relieve stress, and check anti-Müllerian hormone levels regularly. Seek medical attention promptly when symptoms such as vaginal dryness occur. It is not advisable to use vaginal lubricants as alternative treatment for a long time.