The harm of pyridine to boys

Pyridine, an organic chemical compound, is a six-membered heterocyclic compound with a nitrogen molecule. It can be regarded as a compound in which one (CH) in the benzene molecular structure is replaced by N, so it is also called nitrogen benzene. It is a colorless or slightly yellow liquid with a foul smell. Pyridine and its homologues exist in bone nicotine, medium-temperature coal tar, liquefied gas, shale oil, and crude oil.

The pharmaceutical efficacy and action vaccine is a carboxamide compound of sodium salicylate and sulfapyridine. After oral administration, most of them are converted into 5-aminosalicylic acid (mesalazine) and sulfapyridine by microorganisms in the alkaline gastrointestinal environment after oral administration. The latter one is digested and has a weak antibacterial effect. It plays an important role as a mediator in the drug molecular formula and prevents 5-Aminosalicylic acid is digested in the stomach and duodenum. Under the alkaline conditions of the gastrointestinal tract, intestinal microorganisms crack the diazo bonds and release 5-aminosalicylic acid, which fully exerts its anti-infective and immunosuppressive effects. It is used for the treatment of mild ulcerative colitis, auxiliary treatment of mild to moderate ulcerative colitis, and prevention of the onset of ulcerative colitis.

After oral administration, part of the drug is digested in the digestive system and can enter the gastrointestinal tract (enterohepatic circulation) again according to the bile fluid. The undigested drug is dissolved by pathogenic bacteria in the tail ileum and sigmoid colon into 5-aminosalicylic acid (5ASA) and sulfapyridine. Most of the remainder is excreted in the feces. After digestion, sulfapyridine is metabolized in the liver and metabolized by the kidneys, while only 1/3 of mesalazine is digested, and the rest is excreted with the feces after exerting a therapeutic effect in the gastrointestinal tract.

Production and operation methods and requirements Vaccine requirements for adolescents and children: Oral, >2 years old, 10~15mg/kg each time, 4 times a day. After symptoms are relieved, it can be changed to a maintenance dose of 7.5~10Mg/kg each time, 3 or 4 times a day. Adult requirements Dosage: Take orally, 0.5~7.5g each time, 4 times a day. If no symptoms occur, it can be gradually increased to 1~1.5g each time, 4 times a day. The maximum requirement is 8g per day. After symptoms are relieved, the maintenance dose can be changed to 0.5g each time, 3 or 4 times a day.

Common production problems, side effects and damage to vaccines, blood pressure, skin allergies to this product or sulfonamide drugs, sodium salicylate drugs, use of blood platelets in adolescents and children <2 years old, agranulocytosis, gastrointestinal or urethral orifice obstruction, hematoporphyria, glucose delta sulfate is strictly prohibited Use with caution in patients with ammonium dehydrogenase deficiency, asthma, liver and kidney insufficiency, and anabolic bronchitis. Supplement for widespread nausea and vomiting, abdominal discomfort, dysphagia, diarrhea, etc. Pancreatitis, colitis, etc. are rare. Weight-bearing may occasionally cause anabolic bronchitis. Tracheitis. At term, there are headaches, dizziness, abducens neuropathy, transverse myelitis, convulsions, insomnia, depression, acute infectious polyneuritis and ataxia, etc.; it can also cause hallucinations, drowsiness, severe acute encephalopathy, language Hardship, epilepsy and sterile test-induced meningitis. Tubes can cause leukopenia or increase, thrombocytopenia, monocyte count, etc., and can also cause megaloblastic anemia, remodeling disorder anemia, hemolytic anemia, etc. caused by folic acid deficiency.